Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1

We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. Long-term treatment showed no clear evidence of the development of drug resistance....

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Detalhes bibliográficos
Publicado no:Arch Virol
Main Authors: Li, Yunlong, Miao, Zhijiang, Li, Pengfei, Zhang, Ruyi, Kainov, Denis E., Ma, Zhongren, de Man, Robert A., Peppelenbosch, Maikel P., Pan, Qiuwei
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Vienna 2021
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119233/
https://ncbi.nlm.nih.gov/pubmed/33987753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00705-021-05096-w
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