ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility

ORM1-like 3 (ORMDL3) has strong genetic linkage to childhood onset asthma. To determine whether ORMDL3 selective expression in airway smooth muscle (ASM) influences ASM function, we used Cre-loxP techniques to generate transgenic mice (hORMDL3(Myh11eGFP-cre)), which express human ORMDL3 selectively...

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Publicado en:JCI Insight
Autores principales: Pham, Alexa K., Miller, Marina, Rosenthal, Peter, Das, Sudipta, Weng, Ning, Jang, Sunghoon, Kurten, Richard C., Badrani, Jana, Doherty, Taylor A., Oliver, Brian, Broide, David H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119187/
https://ncbi.nlm.nih.gov/pubmed/33661765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136911
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