Selective targeting of KRAS-driven lung tumorigenesis via unresolved ER stress

Lung cancer with oncogenic KRAS makes up a significant proportion of lung cancers and is accompanied by a poor prognosis. Recent advances in understanding the molecular pathogenesis of lung cancer with oncogenic KRAS have enabled the development of drugs, yet mutated KRAS remains undruggable. We per...

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Foilsithe in:JCI Insight
Main Authors: Shimomura, Iwao, Watanabe, Naoaki, Yamamoto, Tomofumi, Kumazaki, Minami, Tada, Yuji, Tatsumi, Koichiro, Ochiya, Takahiro, Yamamoto, Yusuke
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2021
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119185/
https://ncbi.nlm.nih.gov/pubmed/33830081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137876
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