AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?

The serine/threonine kinase AKT is a key component of the PI3K/AKT/mTOR signaling pathway as it exerts a pivotal role in cell growth, proliferation, survival, and metabolism. Deregulation of this pathway is a common event in breast cancer including hormone receptor-positive (HR+) disease, HER2-ampli...

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Vydáno v:Front Pharmacol
Hlavní autoři: Martorana, Federica, Motta, Gianmarco, Pavone, Giuliana, Motta, Lucia, Stella, Stefania, Vitale, Silvia Rita, Manzella, Livia, Vigneri, Paolo
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118639/
https://ncbi.nlm.nih.gov/pubmed/33995085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.662232
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