DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells

BACKGROUND: Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer. DNGR-1 (CLEC9A) is a dead cell-sensing receptor highly restricted to cDC1s. DNGR-1 has been involved i...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Immunother Cancer
Auteurs principaux: Cueto, Francisco J, del Fresno, Carlos, Brandi, Paola, Combes, Alexis J., Hernández-García, Elena, Sánchez-Paulete, Alfonso R, Enamorado, Michel, Bromley, Christian P, Gomez, Manuel J, Conde-Garrosa, Ruth, Mañes, Santos, Zelenay, Santiago, Melero, Ignacio, Iborra, Salvador, Krummel, Matthew F., Sancho, David
Format: Artigo
Langue:Inglês
Publié: BMJ Publishing Group 2021
Sujets:
Basic Tumor Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118081/
https://ncbi.nlm.nih.gov/pubmed/33980589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-002054
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