Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis

BACKGROUND: Both advanced glycation end products (AGEs) and AGE-mediated M1 macrophage polarization contribute to bone marrow mesenchymal stem cell (BMSC) dysfunction, leading to impaired bone regeneration in type 1 diabetes mellitus (T1DM). Adrenomedullin 2 (ADM2), an endogenous bioactive peptide b...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Wang, Feng, Kong, Lingchi, Wang, Wenbo, Shi, Li, Wang, Mengwei, Chai, Yimin, Xu, Jia, Kang, Qinglin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8117361/
https://ncbi.nlm.nih.gov/pubmed/33985585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02368-9
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