Exosomes derived from human CD34(+) stem cells transfected with miR-26a prevent glucocorticoid-induced osteonecrosis of the femoral head by promoting angiogenesis and osteogenesis

BACKGROUND: Damaged endothelial cells and downregulated osteogenic ability are two key pathogenic mechanisms of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Recent studies suggested that transplantation of CD34(+) stem cell-derived exosomes (CD34(+)-Exos) can treat ischemic...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: Zuo, Rongtai, Kong, Lingchi, Wang, Mengwei, Wang, Wenbo, Xu, Jia, Chai, Yimin, Guan, Junjie, Kang, Qinglin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858646/
https://ncbi.nlm.nih.gov/pubmed/31730486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-019-1426-3
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