Mesenchymal stromal cell delivery of oncolytic immunotherapy improves CAR-T cell antitumor activity

The immunosuppressive tumor microenvironment (TME) is a formidable barrier to the success of adoptive cell therapies for solid tumors. Oncolytic immunotherapy with engineered adenoviruses (OAd) may disrupt the TME by infecting tumor cells, as well as surrounding stroma, to improve the functionality...

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Detaylı Bibliyografya
Yayımlandı:Mol Ther
Asıl Yazarlar: McKenna, Mary K., Englisch, Alexander, Brenner, Benjamin, Smith, Tyler, Hoyos, Valentina, Suzuki, Masataka, Brenner, Malcolm K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Gene & Cell Therapy 2021
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116608/
https://ncbi.nlm.nih.gov/pubmed/33571680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2021.02.004
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