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Mesenchymal stromal cell delivery of oncolytic immunotherapy improves CAR-T cell antitumor activity

The immunosuppressive tumor microenvironment (TME) is a formidable barrier to the success of adoptive cell therapies for solid tumors. Oncolytic immunotherapy with engineered adenoviruses (OAd) may disrupt the TME by infecting tumor cells, as well as surrounding stroma, to improve the functionality...

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Bibliografski detalji
Izdano u:Mol Ther
Glavni autori: McKenna, Mary K., Englisch, Alexander, Brenner, Benjamin, Smith, Tyler, Hoyos, Valentina, Suzuki, Masataka, Brenner, Malcolm K.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116608/
https://ncbi.nlm.nih.gov/pubmed/33571680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2021.02.004
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