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Mesenchymal stromal cell delivery of oncolytic immunotherapy improves CAR-T cell antitumor activity
The immunosuppressive tumor microenvironment (TME) is a formidable barrier to the success of adoptive cell therapies for solid tumors. Oncolytic immunotherapy with engineered adenoviruses (OAd) may disrupt the TME by infecting tumor cells, as well as surrounding stroma, to improve the functionality...
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| Publicado en: | Mol Ther |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Gene & Cell Therapy
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8116608/ https://ncbi.nlm.nih.gov/pubmed/33571680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2021.02.004 |
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