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Prodrugs and prodrug-activated systems in gene therapy
The inclusion of genes that control cell fate (so-called suicide, or kill-switch, genes) into gene therapy vectors is based on a compelling rationale for the safe and selective elimination of aberrant transfected cells. Prodrug-activated systems were developed in the 1980s and 1990s and rely on the...
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| Publicado no: | Mol Ther |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Gene & Cell Therapy
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8116605/ https://ncbi.nlm.nih.gov/pubmed/33831557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2021.04.006 |
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