α6GABA(A) Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia

Migraine is caused by hyperactivity of the trigeminovascular system, where trigeminal ganglia (TG) play an important role. This hyperactivity might originate from an underfunctional GABAergic system in TG. To investigate this possibility, we adapted a mouse model of migraine by inducing migraine-lik...

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Publicado en:Neurotherapeutics
Autores principales: Tzeng, Hung-Ruei, Lee, Ming Tatt, Fan, Pi-Chuan, Knutson, Daniel E., Lai, Tzu-Hsuan, Sieghart, Werner, Cook, James, Chiou, Lih-Chu
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer International Publishing 2020
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116449/
https://ncbi.nlm.nih.gov/pubmed/33111258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-020-00951-1
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