The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands

CpG islands (CGIs) are key regulatory DNA elements at most promoters, but how they influence the chromatin status and transcription remains elusive. Here, we identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-binding protein. SAMD1 has an atypical winged-helix d...

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Detaylı Bibliyografya
Yayımlandı:Sci Adv
Asıl Yazarlar: Stielow, Bastian, Zhou, Yuqiao, Cao, Yinghua, Simon, Clara, Pogoda, Hans-Martin, Jiang, Junyi, Ren, Yanpeng, Phanor, Sabrina Keita, Rohner, Iris, Nist, Andrea, Stiewe, Thorsten, Hammerschmidt, Matthias, Shi, Yang, Bulyk, Martha L., Wang, Zhanxin, Liefke, Robert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Association for the Advancement of Science 2021
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115922/
https://ncbi.nlm.nih.gov/pubmed/33980486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf2229
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