The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands

CpG islands (CGIs) are key regulatory DNA elements at most promoters, but how they influence the chromatin status and transcription remains elusive. Here, we identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-binding protein. SAMD1 has an atypical winged-helix d...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Stielow, Bastian, Zhou, Yuqiao, Cao, Yinghua, Simon, Clara, Pogoda, Hans-Martin, Jiang, Junyi, Ren, Yanpeng, Phanor, Sabrina Keita, Rohner, Iris, Nist, Andrea, Stiewe, Thorsten, Hammerschmidt, Matthias, Shi, Yang, Bulyk, Martha L., Wang, Zhanxin, Liefke, Robert
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115922/
https://ncbi.nlm.nih.gov/pubmed/33980486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf2229
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