DEAF1 Binds Unmethylated and Variably Spaced CpG Dinucleotide Motifs

DEAF1 is a transcriptional regulator associated with autoimmune and neurological disorders and is known to bind TTCG motifs. To further ascertain preferred DEAF1 DNA ligands, we screened a random oligonucleotide library containing an “anchored” CpG motif. We identified a binding consensus that gener...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jensik, Philip J., Vargas, Jesse D., Reardon, Sara N., Rajamanickam, Shivakumar, Huggenvik, Jodi I., Collard, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274154/
https://ncbi.nlm.nih.gov/pubmed/25531106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115908
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