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SMALL MOLECULE IMAGING AGENT FOR MUTANT KRAS G12C

Multiple potent covalent inhibitors for mutant KRAS G12C have been described and some are in clinical trials. These small molecule inhibitors potentially allow for companion imaging probe development, thereby expanding the chemical biology toolkit to investigate mutant KRAS biology. Herein, we synth...

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Detalhes bibliográficos
Publicado no:Adv Ther (Weinh)
Main Authors: Koch, Peter D., Quintana, Jeremy, Ahmed, Maaz, Kohler, Rainer H., Weissleder, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115719/
https://ncbi.nlm.nih.gov/pubmed/33997272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adtp.202000290
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