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SMALL MOLECULE IMAGING AGENT FOR MUTANT KRAS G12C

Multiple potent covalent inhibitors for mutant KRAS G12C have been described and some are in clinical trials. These small molecule inhibitors potentially allow for companion imaging probe development, thereby expanding the chemical biology toolkit to investigate mutant KRAS biology. Herein, we synth...

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Bibliographic Details
Published in:Adv Ther (Weinh)
Main Authors: Koch, Peter D., Quintana, Jeremy, Ahmed, Maaz, Kohler, Rainer H., Weissleder, Ralph
Format: Artigo
Language:Inglês
Published: 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115719/
https://ncbi.nlm.nih.gov/pubmed/33997272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adtp.202000290
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