Deletions in FLT-3 juxtamembrane domain define a new class of pathogenic mutations: case report and systematic analysis

The FMS-like tyrosine kinase 3 (FLT-3) is the most frequently mutated gene in acute myeloid leukemia (AML), a high-risk feature, and now the target of tyrosine kinase inhibitors (TKIs), which are approved and in development. The most common mutation is the internal tandem duplication (ITD). We prese...

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Publicado en:Blood Adv
Main Authors: Young, David J., Nguyen, Bao, Zhu, Ruiqi, Seo, Jaesung, Li, Li, Levis, Mark J., Pratz, Keith W., Duffield, Amy S., Small, Donald
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2021
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8114556/
https://ncbi.nlm.nih.gov/pubmed/33914060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002876
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