Population Pharmacokinetics and Initial Dose Optimization of Sirolimus Improving Drug Blood Level for Seizure Control in Pediatric Patients With Tuberous Sclerosis Complex

The purposes of this study were to explore the population pharmacokinetics and initial dose optimization of sirolimus improving drug blood level for seizure control in pediatric patients with tuberous sclerosis complex (TSC). Eighty pediatric patients diagnosed with TSC-related epilepsy were include...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Chen, Xiao, Wang, Dongdong, Zhu, Lin, Lu, Jinmiao, Huang, Yidie, Wang, Guangfei, Zhu, Yiqing, Ye, Qiaofeng, Wang, Yi, Xu, Hong, Li, Zhiping
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8114543/
https://ncbi.nlm.nih.gov/pubmed/33995061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.647232
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