Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

BACKGROUND: Angiomyolipomas in patients with the tuberous sclerosis complex or sporadic lymphangioleiomyomatosis are associated with mutations in tuberous sclerosis genes resulting in constitutive activation of the mammalian target of rapamycin (mTOR). The drug sirolimus suppresses mTOR signaling. M...

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Bibliografiset tiedot
Päätekijät: Bissler, John J., McCormack, Francis X., Young, Lisa R., Elwing, Jean M., Chuck, Gail, Leonard, Jennifer M., Schmithorst, Vincent J., Laor, Tal, Brody, Alan S., Bean, Judy, Salisbury, Shelia, Franz, David N.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398441/
https://ncbi.nlm.nih.gov/pubmed/18184959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa063564
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