Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

BACKGROUND: Angiomyolipomas in patients with the tuberous sclerosis complex or sporadic lymphangioleiomyomatosis are associated with mutations in tuberous sclerosis genes resulting in constitutive activation of the mammalian target of rapamycin (mTOR). The drug sirolimus suppresses mTOR signaling. M...

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Detaylı Bibliyografya
Asıl Yazarlar: Bissler, John J., McCormack, Francis X., Young, Lisa R., Elwing, Jean M., Chuck, Gail, Leonard, Jennifer M., Schmithorst, Vincent J., Laor, Tal, Brody, Alan S., Bean, Judy, Salisbury, Shelia, Franz, David N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398441/
https://ncbi.nlm.nih.gov/pubmed/18184959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa063564
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