Pharmacokinetics and pharmacodynamics of everolimus in patients with renal angiomyolipoma and tuberous sclerosis complex or lymphangioleiomyomatosis

AIMS: The purpose was to determine the exposure−response relationship of everolimus in patients with angiomyolipoma from the EXIST‐2 trial and to analyze the correlation between exposure and plasma concentrations of angiogenic biomarkers in these patients. METHODS: One hundred and eighteen patients...

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Publicado en:Br J Clin Pharmacol
Autores principales: Budde, Klemens, Zonnenberg, Bernard A., Frost, Michael, Cheung, Wing, Urva, Shweta, Brechenmacher, Thomas, Stein, Karen, Chen, David, Kingswood, John Christopher, Bissler, John J.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Pharmacokinetic Dynamic Relationships
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834586/
https://ncbi.nlm.nih.gov/pubmed/26580489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12834
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