Sensitive FRET Biosensor Reveals Fyn Kinase Regulation by Submembrane Localization

Fyn kinase plays crucial roles in hematology and T cell signaling; however, there are currently limited tools to visualize the dynamic Fyn activity in live cells. Here we developed and characterized a highly sensitive Fyn biosensor based on fluorescence resonance energy transfer (FRET) to monitor Fy...

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Bibliografische gegevens
Gepubliceerd in:ACS Sens
Hoofdauteurs: Ouyang, Mingxing, Wan, Rongxue, Qin, Qin, Peng, Qin, Wang, Pengzhi, Wu, Jenny, Allen, Molly, Shi, Yiwen, Laub, Shannon, Deng, Linhong, Lu, Shaoying, Wang, Yingxiao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8114461/
https://ncbi.nlm.nih.gov/pubmed/30588803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssensors.8b00896
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