Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor

Lck plays crucial roles in TCR signaling. We developed a new and sensitive FRET biosensor (ZapLck) to visualize Lck kinase activity with high spatiotemporal resolutions in live cells. ZapLck revealed that 62% of Lck signal was preactivated in T-cells. In Lck-deficient JCam T-cells, Lck preactivation...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Wan, Rongxue, Wu, Jenny, Ouyang, Mingxing, Lei, Lei, Wei, Jiaming, Peng, Qin, Harrison, Reed, Wu, Yiqian, Cheng, Binbin, Li, Kaitao, Zhu, Cheng, Tang, Liling, Wang, Yingxiao, Lu, Shaoying
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6584686/
https://ncbi.nlm.nih.gov/pubmed/31223643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau2001
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