Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease

Translocator protein (TSPO, 18 kDa) levels increase in parallel with the evolution of simple steatosis (SS) to nonalcoholic steatohepatitis (NASH) in nonalcoholic fatty liver disease (NAFLD). However, TSPO function in SS and NASH is unknown. Loss of TSPO in hepatocytes in vitro downregulated acetyl-...

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Gepubliceerd in:iScience
Hoofdauteurs: Li, Yuchang, Chen, Liting, Li, Lu, Sottas, Chantal, Petrillo, Stephanie K., Lazaris, Anthoula, Metrakos, Peter, Wu, Hangyu, Ishida, Yuji, Saito, Takeshi, Golden-Mason, Lucy, Rosen, Hugo R., Wolff, Jeremy J., Silvescu, Cristina I., Garza, Samuel, Cheung, Garett, Huang, Tiffany, Fan, Jinjiang, Culty, Martine, Stiles, Bangyan, Asahina, Kinji, Papadopoulos, Vassilios
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113880/
https://ncbi.nlm.nih.gov/pubmed/34013171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102457
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