Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease

Translocator protein (TSPO, 18 kDa) levels increase in parallel with the evolution of simple steatosis (SS) to nonalcoholic steatohepatitis (NASH) in nonalcoholic fatty liver disease (NAFLD). However, TSPO function in SS and NASH is unknown. Loss of TSPO in hepatocytes in vitro downregulated acetyl-...

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Vydáno v:iScience
Hlavní autoři: Li, Yuchang, Chen, Liting, Li, Lu, Sottas, Chantal, Petrillo, Stephanie K., Lazaris, Anthoula, Metrakos, Peter, Wu, Hangyu, Ishida, Yuji, Saito, Takeshi, Golden-Mason, Lucy, Rosen, Hugo R., Wolff, Jeremy J., Silvescu, Cristina I., Garza, Samuel, Cheung, Garett, Huang, Tiffany, Fan, Jinjiang, Culty, Martine, Stiles, Bangyan, Asahina, Kinji, Papadopoulos, Vassilios
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113880/
https://ncbi.nlm.nih.gov/pubmed/34013171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102457
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