In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editors

Gene manipulation is a useful approach for understanding functions of genes and is important for investigating basic mechanisms of brain function on the level of single neurons and circuits. Despite the development and the wide range of applications of CRISPR-Cas9 and base editors (BEs), their imple...

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Vydáno v:Comput Struct Biotechnol J
Hlavní autoři: Song, Beomjong, Kang, Chan Young, Han, Jun Hee, Kano, Masanobu, Konnerth, Arthur, Bae, Sangsu
Médium: Artigo
Jazyk:Inglês
Vydáno: Research Network of Computational and Structural Biotechnology 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113754/
https://ncbi.nlm.nih.gov/pubmed/34025938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2021.04.051
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