Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer

Resistance to Herceptin represents a significant challenge for successful treatment of HER2-positive breast cancer. Here, we show that in Herceptin-sensitive cells, FOXO3a regulates specific miRNAs to control IGF2 and IRS1 expression, retaining basic IGF2/IGF-1R/IRS1 signaling. The basic activity ma...

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Publicat a:Nat Commun
Autors principals: Luo, Liyun, Zhang, Zhijie, Qiu, Ni, Ling, Li, Jia, Xiaoting, Song, Ying, Li, Hongsheng, Li, Jiansheng, Lyu, Hui, Liu, Hao, He, Zhimin, Liu, Bolin, Zheng, Guopei
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113606/
https://ncbi.nlm.nih.gov/pubmed/33976188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23052-9
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