The miR-491-3p/mTORC2/FOXO1 regulatory loop modulates chemo-sensitivity in human tongue cancer

We found that levels of miR-491-3p were decreased in multidrug-resistant tongue cancer (TC) cells. Induction of miR-491-3p expression sensitized TC cells to chemotherapy. In agreement, functional inhibition of miR-491-3p enhanced resistance of TC cells to chemotherapy. We found that miR-491-3p direc...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zheng, Guopei, Jia, Xiaoting, Peng, Cong, Deng, Yingen, Yin, Jiang, Zhang, Zhijie, Li, Nan, Deng, Min, Liu, Xiaorong, Liu, Hao, Lu, Minying, Wang, Chengkun, Gu, Yixue, He, Zhimin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466660/
https://ncbi.nlm.nih.gov/pubmed/25749387
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