The 14-3-3σ/GSK3β/β-catenin/ZEB1 regulatory loop modulates chemo-sensitivity in human tongue cancer

Here we demonstrated that chemotherapy induced 14-3-3σ expression in tongue cancer (TC) cells and overexpressed 14-3-3σ sensitized TC cells to chemotherapy especially in multidrug resistant TC (MDR-TC) cells. In agreement, 14-3-3σ knockdown enhanced resistance of TC cells to chemotherapy. Mechanical...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Peng, Cong, Jia, Xiaoting, Xiong, Yan, Yin, Jiang, Li, Nan, Deng, Yingen, Luo, Kai, Zhang, Qiong, Wang, Chengkun, Zhang, Zhijie, Zheng, Guopei, He, Zhimin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652996/
https://ncbi.nlm.nih.gov/pubmed/26036631
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