An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness

Notch signaling represents a key mechanism mediating cancer metastasis and stemness. To understand how Notch signaling is overactivated to couple tumor metastasis and self-renewal in NSCLC cells, we performed the current study and showed that RFC4, a DNA replication factor amplified in more than 40%...

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Publicado no:Nat Commun
Main Authors: Liu, Lei, Tao, Tianyu, Liu, Shihua, Yang, Xia, Chen, Xuwei, Liang, Jiaer, Hong, Ruohui, Wang, Wenting, Yang, Yi, Li, Xiaoyi, Zhang, Youhong, Li, Quanfeng, Liang, Shujun, Yu, Haocheng, Wu, Yun, Guo, Xinyu, Lai, Yan, Ding, Xiaofan, Guan, Hongyu, Wu, Jueheng, Zhu, Xun, Yuan, Jie, Li, Jun, Su, Shicheng, Li, Mengfeng, Cai, Xiuyu, Cai, Junchao, Tian, Han
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113560/
https://ncbi.nlm.nih.gov/pubmed/33976158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22971-x
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