AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation

Despite the importance of AKT overactivation in tumor progression, results from clinical trials of various AKT inhibitors remain suboptimal, suggesting that AKT-driven tumor metastasis needs to be further understood. Herein, based on long non-coding RNA (lncRNA) profiling induced by active AKT, we i...

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Publicado en:Nat Commun
Main Authors: Tian, Han, Lian, Rong, Li, Yun, Liu, Chenying, Liang, Shujun, Li, Wei, Tao, Tianyu, Wu, Xingui, Ye, Yaokai, Yang, Xia, Han, Jian, Chen, Xuwei, Li, Jun, He, Yukai, Li, Mengfeng, Wu, Jueheng, Cai, Junchao
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550350/
https://ncbi.nlm.nih.gov/pubmed/33046716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18929-0
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