IDH2 mutations in patients with normal karyotype AML predict favorable responses to daunorubicin, cytarabine and cladribine regimen

Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) genes occur in about 20% patients with acute myeloid leukemia (AML), leading to DNA hypermethylation and epigenetic deregulation. We assessed the prognostic significance of IDH1/2 mutations (IDH1/2(+)) in 398 AML patients with normal karyotype (...

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Publicado no:Sci Rep
Main Authors: Libura, Marta, Bialopiotrowicz, Emilia, Giebel, Sebastian, Wierzbowska, Agnieszka, Roboz, Gail J., Piatkowska-Jakubas, Beata, Pawelczyk, Marta, Gorniak, Patryk, Borg, Katarzyna, Wojtas, Magdalena, Florek, Izabella, Matiakowska, Karolina, Jazwiec, Bozena, Solarska, Iwona, Noyszewska-Kania, Monika, Piechna, Karolina, Zawada, Magdalena, Czekalska, Sylwia, Salamanczuk, Zoriana, Karabin, Karolina, Wasilewska, Katarzyna, Paluszewska, Monika, Urbanowska, Elzbieta, Gajkowska-Kulik, Justyna, Semenczuk, Grazyna, Rybka, Justyna, Wrobel, Tomasz, Ejduk, Anna, Kata, Dariusz, Grosicki, Sebastian, Robak, Tadeusz, Pluta, Agnieszka, Kominek, Agata, Piwocka, Katarzyna, Pyziak, Karolina, Sroka-Porada, Agnieszka, Wrobel, Anna, Przybylowicz, Agnieszka, Wojtaszewska, Marzena, Lewandowski, Krzysztof, Gil, Lidia, Piekarska, Agnieszka, Knopinska, Wanda, Bolkun, Lukasz, Warzocha, Krzysztof, Kuliczkowski, Kazimierz, Sacha, Tomasz, Basak, Grzegorz, Jedrzejczak, Wieslaw Wiktor, Holowiecki, Jerzy, Juszczynski, Przemysław, Haus, Olga
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113255/
https://ncbi.nlm.nih.gov/pubmed/33976256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88120-y
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