Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models

Most anti-influenza drugs currently used, such as oseltamivir and zanamivir, inhibit the enzymatic activity of neuraminidase. However, neuraminidase inhibitor-resistant viruses have already been identified from various influenza virus isolates. Here, we report the development of a class of macrocycl...

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Publicado no:Nat Commun
Main Authors: Saito, Makoto, Itoh, Yasushi, Yasui, Fumihiko, Munakata, Tsubasa, Yamane, Daisuke, Ozawa, Makoto, Ito, Risa, Katoh, Takayuki, Ishigaki, Hirohito, Nakayama, Misako, Shichinohe, Shintaro, Yamaji, Kenzaburo, Yamamoto, Naoki, Ikejiri, Ai, Honda, Tomoko, Sanada, Takahiro, Sakoda, Yoshihiro, Kida, Hiroshi, Le, Thi Quynh Mai, Kawaoka, Yoshihiro, Ogasawara, Kazumasa, Tsukiyama-Kohara, Kyoko, Suga, Hiroaki, Kohara, Michinori
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113231/
https://ncbi.nlm.nih.gov/pubmed/33976181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22964-w
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