Pan-cancer landscape of CD274 (PD-L1) copy number changes in 244 584 patient samples and the correlation with PD-L1 protein expression

INTRODUCTION: Several studies have shown clinical outcomes data that support the use of CD274 (PD-L1) copy-number (CN) gains and/or losses as a biomarker for immune checkpoint inhibitor (ICPI). Here, we present the landscape of CD274 CN changes across a large cohort of solid tumor cases and correlat...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Huang, Richard S.P., Murugesan, Karthikeyan, Montesion, Meagan, Pavlick, Dean C., Mata, Douglas A., Hiemenz, Matthew C., Decker, Brennan, Frampton, Garrett, Albacker, Lee A., Ross, Jeffrey S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2021
Schlagworte:
Immunotherapy Biomarkers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8112409/
https://ncbi.nlm.nih.gov/pubmed/33972391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002680
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