Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8(+) but not CD4(+) T cells

Because of their common signaling molecules, the main T cell receptor (TCR) signaling cascades in CD4(+) and CD8(+) T cells are considered qualitatively identical. Herein, we show that TCR signaling in CD8(+) T cells is qualitatively different from that in CD4(+) T cells, since CD8α ignites another...

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Udgivet i:J Exp Med
Main Authors: Sasai, Miwa, Ma, Ji Su, Okamoto, Masaaki, Nishino, Kohei, Nagaoka, Hikaru, Takashima, Eizo, Pradipta, Ariel, Lee, Youngae, Kosako, Hidetaka, Suh, Pann-Ghill, Yamamoto, Masahiro
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111461/
https://ncbi.nlm.nih.gov/pubmed/33970189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201763
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