I(2) imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway

Brain aging and dementia are current problems that must be solved. The levels of imidazoline 2 receptors (I(2)-IRs) are increased in the brain in Alzheimer’s disease (AD) and other neurodegenerative diseases. We tested the action of the specific and selective I(2)-IR ligand B06 in a mouse model of a...

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Detalhes bibliográficos
Publicado no:GeroScience
Main Authors: Vasilopoulou, Foteini, Griñán-Ferré, Christian, Rodríguez-Arévalo, Sergio, Bagán, Andrea, Abás, Sònia, Escolano, Carmen, Pallàs, Mercè
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110656/
https://ncbi.nlm.nih.gov/pubmed/33128688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00281-2
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