IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging

Aging is associated with a significant deficiency in circulating insulin-like growth factor-1 (IGF-1), which has an important role in the pathogenesis of age-related vascular cognitive impairment (VCI). Impairment of moment-to-moment adjustment of regional cerebral blood flow via neurovascular coupl...

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Détails bibliographiques
Publié dans:GeroScience
Auteurs principaux: Tarantini, Stefano, Balasubramanian, Priya, Yabluchanskiy, Andriy, Ashpole, Nicole M., Logan, Sreemathi, Kiss, Tamas, Ungvari, Anna, Nyúl-Tóth, Ádám, Schwartzman, Michal L., Benyo, Zoltan, Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan
Format: Artigo
Langue:Inglês
Publié: Springer International Publishing 2021
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110646/
https://ncbi.nlm.nih.gov/pubmed/33674953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-021-00350-0
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