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Pathogenic missense protein variants affect different functional pathways and proteomic features than healthy population variants

Missense variants are present amongst the healthy population, but some of them are causative of human diseases. A classification of variants associated with “healthy” or “diseased” states is therefore not always straightforward. A deeper understanding of the nature of missense variants in health and...

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Publicat a:PLoS Biol
Autors principals: Laddach, Anna, Ng, Joseph Chi Fung, Fraternali, Franca
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110273/
https://ncbi.nlm.nih.gov/pubmed/33909605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001207
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