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Short loop functional commonality identified in leukaemia proteome highlights crucial protein sub-networks

Direct drug targeting of mutated proteins in cancer is not always possible and efficacy can be nullified by compensating protein–protein interactions (PPIs). Here, we establish an in silico pipeline to identify specific PPI sub-networks containing mutated proteins as potential targets, which we appl...

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Bibliografiske detaljer
Udgivet i:NAR Genom Bioinform
Main Authors: Chung, Sun Sook, Ng, Joseph C F, Laddach, Anna, Thomas, N Shaun B, Fraternali, Franca
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936661/
https://ncbi.nlm.nih.gov/pubmed/33709075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nargab/lqab010
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