Influenza A virus NS1 induces degradation of sphingosine 1-phosphate lyase to obstruct the host innate immune response

The type I interferon (IFN)-mediated innate immune response is one of the central obstacles influenza A virus (IAV) must overcome in order to successfully replicate within the host. We have previously shown that sphingosine 1-phosphate (S1P) lyase (SPL) enhances IKKɛ-mediated type I IFN responses. H...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Wolf, Jennifer J., Xia, Chuan, Studstill, Caleb J., Ngo, Hanh, Brody, Steven L., Anderson, Paul E., Hahm, Bumsuk
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8109848/
https://ncbi.nlm.nih.gov/pubmed/33730651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2021.02.006
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