Sphingosine 1-phosphate lyase enhances the activation of IKKε to promote type I interferon-mediated innate immune response to influenza A virus infection

Sphingosine 1-phosphate (S1P) lyase (SPL) is an intracellular enzyme that mediates the irreversible degradation of the bioactive lipid, S1P. We have previously reported that overexpressed SPL displays anti-influenza viral activity; however the underlying mechanism is incompletely understood. In this...

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Publicado no:J Immunol
Main Authors: Vijayan, Madhuvanthi, Xia, Chuan, Song, Yul Eum, Ngo, Hanh, Studstill, Caleb J., Drews, Kelly, Fox, Todd E., Johnson, Marc C., Hiscott, John, Kester, Mark, Alexander, Stephen, Hahm, Bumsuk
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528153/
https://ncbi.nlm.nih.gov/pubmed/28600291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601959
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