Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence

Chronic viral infections are often established by the exploitation of immune-regulatory mechanisms that result in nonfunctional T cell responses. Viruses that establish persistent infections remain a serious threat to human health. Sphingosine kinase 2 (SphK2) generates sphingosine 1-phosphate, whic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Studstill, Caleb J., Pritzl, Curtis J., Seo, Young-Jin, Kim, Dae Young, Xia, Chuan, Wolf, Jennifer J., Nistala, Ravi, Vijayan, Madhuvanthi, Cho, Yong-Bin, Kang, Kyung Won, Lee, Sang-Myeong, Hahm, Bumsuk
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685747/
https://ncbi.nlm.nih.gov/pubmed/32897877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125297
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