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Influenza A virus NS1 induces degradation of sphingosine 1-phosphate lyase to obstruct the host innate immune response
The type I interferon (IFN)-mediated innate immune response is one of the central obstacles influenza A virus (IAV) must overcome in order to successfully replicate within the host. We have previously shown that sphingosine 1-phosphate (S1P) lyase (SPL) enhances IKKɛ-mediated type I IFN responses. H...
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| Veröffentlicht in: | Virology |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8109848/ https://ncbi.nlm.nih.gov/pubmed/33730651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2021.02.006 |
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