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The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80

Par1b/MARK2 is a Ser/Thr kinase with pleiotropic effects that participates in the generation of apico-basal polarity in Caenorhabditis elegans. It is phosphorylated by atypical PKC(ι/λ) in Thr595 and inhibited. Because previous work showed a decrease in atypical protein kinase C (aPKC) activity unde...

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Publié dans:Mol Biol Cell
Auteurs principaux: Mashukova, Anastasia, Forteza, Radia, Shah, Viraj N., Salas, Pedro J.
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2021
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8108508/
https://ncbi.nlm.nih.gov/pubmed/33596087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-10-0646
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