HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers

BACKGROUND: Cellular senescence is a permanent state of replicative arrest defined by a specific pattern of gene expression. The epigenome in senescent cells is sculptured in order to sustain the new transcriptional requirements, particularly at enhancers and super-enhancers. How these distal regula...

Full description

Saved in:
Bibliographic Details
Published in:Genome Biol
Main Authors: Di Giorgio, Eros, Paluvai, Harikrishnareddy, Dalla, Emiliano, Ranzino, Liliana, Renzini, Alessandra, Moresi, Viviana, Minisini, Martina, Picco, Raffaella, Brancolini, Claudio
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8108360/
https://ncbi.nlm.nih.gov/pubmed/33966634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02340-z
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items