HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers

BACKGROUND: Cellular senescence is a permanent state of replicative arrest defined by a specific pattern of gene expression. The epigenome in senescent cells is sculptured in order to sustain the new transcriptional requirements, particularly at enhancers and super-enhancers. How these distal regula...

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Vydáno v:Genome Biol
Hlavní autoři: Di Giorgio, Eros, Paluvai, Harikrishnareddy, Dalla, Emiliano, Ranzino, Liliana, Renzini, Alessandra, Moresi, Viviana, Minisini, Martina, Picco, Raffaella, Brancolini, Claudio
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8108360/
https://ncbi.nlm.nih.gov/pubmed/33966634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02340-z
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