Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells

Transcriptional networks supervising class IIa HDAC expression are poorly defined. Here we demonstrate that MEF2D is the key factor controlling HDAC9 transcription. This control, which is part of a negative feed-back loop during muscle differentiation, is hijacked in cancer. In leiomyosarcomas the M...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Di Giorgio, Eros, Dalla, Emiliano, Franforte, Elisa, Paluvai, Harikrishnareddy, Minisini, Martina, Trevisanut, Matteo, Picco, Raffaella, Brancolini, Claudio
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954409/
https://ncbi.nlm.nih.gov/pubmed/31754707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1120
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