Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells

Transcriptional networks supervising class IIa HDAC expression are poorly defined. Here we demonstrate that MEF2D is the key factor controlling HDAC9 transcription. This control, which is part of a negative feed-back loop during muscle differentiation, is hijacked in cancer. In leiomyosarcomas the M...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Di Giorgio, Eros, Dalla, Emiliano, Franforte, Elisa, Paluvai, Harikrishnareddy, Minisini, Martina, Trevisanut, Matteo, Picco, Raffaella, Brancolini, Claudio
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Gene regulation, Chromatin and Epigenetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954409/
https://ncbi.nlm.nih.gov/pubmed/31754707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1120
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