Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells

Transcriptional networks supervising class IIa HDAC expression are poorly defined. Here we demonstrate that MEF2D is the key factor controlling HDAC9 transcription. This control, which is part of a negative feed-back loop during muscle differentiation, is hijacked in cancer. In leiomyosarcomas the M...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Di Giorgio, Eros, Dalla, Emiliano, Franforte, Elisa, Paluvai, Harikrishnareddy, Minisini, Martina, Trevisanut, Matteo, Picco, Raffaella, Brancolini, Claudio
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Gene regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954409/
https://ncbi.nlm.nih.gov/pubmed/31754707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1120
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