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NMR unveils an N-terminal interaction interface on acetylated-α-synuclein monomers for recruitment to fibrils
Amyloid fibril formation of α-synuclein (αS) is associated with multiple neurodegenerative diseases, including Parkinson’s disease (PD). Growing evidence suggests that progression of PD is linked to cell-to-cell propagation of αS fibrils, which leads to seeding of endogenous intrinsically disordered...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8106326/ https://ncbi.nlm.nih.gov/pubmed/33903234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017452118 |
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