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Human fetal liver metabolism of oxycodone is mediated by CYP3A7
Oxycodone is an opioid analgesic that is commonly prescribed to pregnant women to treat moderate to severe pain. It has been shown to cross the placenta and distribute to the fetus. Oxycodone is mainly metabolized by CYP3A4 in adult liver. Since CYP3A7 is abundantly expressed in the fetal liver and...
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| 出版年: | AAPS J |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8106324/ https://ncbi.nlm.nih.gov/pubmed/33438174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-020-00537-x |
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